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Citrus Aurantium Clinical Studies
Citrus aurantium as a Thermogenic, Weight-Reduction Replacement for Ephedra: An Overview
"Citrus aurantium appears to be a possible thermogenic substitute for ephedra based upon two studies showing enhanced weight loss compared to control (Colker et al., 1999; Jones, 2001) and three studies reporting increased metabolic rates with its use (Colker et al., 1999; Pathak and Gougeon, 1999; Hedrei and Gougeon, 1997). More studies and widespread use of this natural product will reveal the veracity of the preceding statement as well as the relative safety of Citrus aurantium compared to ephedra. In addition to thermogenesis, this agent might work also via some appetite suppression like ephedra and via its effects on the insulin system. Furthermore, agents that overcome insulin resistance may also be beneficial in increasing metabolism and helping with fat loss in obese subjects without adverse side effects..."
[Harry G. Preuss et al., Citrus aurantium as a Thermogenic, Weight-Reduction Replacement for Ephedra: An Overview, Journal of Medicine (2002) 33(1-4):247-264.]
Potential Applications for Alternative Medicine to Treat Obesity
"Synephrine alkaloids reputed to cause weight loss can be derived from Citrus aurantium, the sour orange. It is unclear which of several alkaloids from the plant actually contribute to weight loss. Although three small trials revealed such alkaloids can increase systolic blood pressure and heart rate, others showed no effect. Investigations of weight loss properties, not all controlled, have been conducted in small numbers of younger subjects. In four of these investigations weight loss ranged from 2.05 to 3.1 kg..."
[E. Paul Cherniack MD, Potential Applications for Alternative Medicine to Treat Obesity in an Aging Population, Alternative Medicine Review (2008) 13(1):34-42.]