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Niacin Clinical Studies

Study #1

 

“Two hundred one male and female subjects, aged 20 to 70 years, with elevated low-density lipoprotein cholesterol values (in the 75th to 95th percentiles), participated in a randomized, controlled, double-blind study using a new form of niacin...The blood lipid results of this study demonstrate the efficacy of relatively modest doses of... niacin in reducing LDL-[cholesterol] levels.”

 

[Joseph M. Keenan MD et al, Niacin Revisited: A Randomized, Controlled Trial of Wax-Matrix Sustained-Release Niacin in Hypercholesterolemia, Archives of Internal Medicine, July 1991, 151:1424-1432]

 

Study #2

 

"Participants: A total of 468 participants, including 125 with diabetes, who had diagnosed peripheral arterial disease.

 

Results: Niacin use significantly increased HDL-C by 29% and 29% and decreased triglycerides by 23% and 28% and low-density lipoprotein cholesterol (LDL-C) by 8% and 9%, respectively, in participants with and without diabetes (P,.001 for niacin vs. placebo for all)."

 

[Marshall B. Elam PhD MD et al, Effect of Niacin on Lipid and Lipoprotein Levels and Glycemic Control in Patients With Diabetes and Peripheral Arterial Disease, Journal of the American Medical Association, September 2000, 284(10):1263-1270]

 
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