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Probiotic Blend Clinical Studies

Study #1

 

An Experimental Study and a Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Antisecretory Activity of Lactobacillus acidophilus Strain LB Against Nonrotavirus Diarrhea.

 

"We have shown experimentally that L acidophilus LB culture or heat-killed L acidophilus LB bacteria plus spent culture medium were able to induce dosage-dependent blockade of the C1845-induced increase in the number of fluid domes in cultured, human intestinal Caco-2/TC7 cells."

 

[Vanessa Lie´vin-Le Moal et al., An Experimental Study and a Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Antisecretory Activity of Lactobacillus acidophilus Strain LB Against Nonrotavirus Diarrhea, Pediatrics, October 2007, 120(4):e795-e804.]

 

Study #2

 

Lactobacillus acidophilus Strain of Human Gastrointestinal Microbiota Origin Elicits Killing of Enterovirulent Salmonella enterica Serovar Typhimurium by Triggering Lethal Bacterial Membrane Damage

 

"It is tempting to suggest that some strains of Lactobacillus that inhabit the intestinal microbiota may discharge an antimicrobial substance(s) into ecological niches within the intestine and thus also contribute to the first line of the chemical defense against enteric pathogens."

 

[Marie-He´le`ne Coconnier-Polter et al., A Lactobacillus acidophilus Strain of Human Gastrointestinal Microbiota Origin Elicits Killing of Enterovirulent Salmonella enterica Serovar Typhimurium by Triggering Lethal Bacterial Membrane Damage, Environmental Microbiology, Oct. 2005, 71(10):6115–6120.]

 

Study #3

 

The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota

 

"The intestinal microbiota plays an important role in normal gut function and in maintaining host health. All the components of the gastrointestinal ecosystem seem to be necessary for the gut to develop its specific intestinal functions. . ."

 

"It has been reported that Lactobacillus inhibited the internalization of S. enterica serovar Typhimurium within human intestinal cells, and this effect had been attributed to a secreted molecule(s) that could affect the virulence factors involved in cell entry and/or block the host cell signal transduction necessary for bacterial internalization."

 

[Vanessa Lie´vin-Le Moal and Alain L. Servin, The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota, Clinical Microbiology Reviews, April 2006, 19(2):315–337.] 

 
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